Endocrine Abstracts

Introduction: Accumulating evidence suggests that one of the most significant contributors to endothelial dysfunction is increased oxidative stress. Excessive reactive oxygen species (ROS) generation can have injurious effects within the vasculature including elevated expression of adhesion molecules, stimulation of vascular smooth muscle cell proliferation, and promotion of endothelial cell apoptosis; events which culminate in the formation and progression of atherosclerotic ...

Introduction: Increased oxidative stress is associated with endothelial dysfunction in atherosclerosis and cardiovascular diseases (CVD). Evidence suggests that tumour necrosis factor-related apoptosis-inducing ligand (TRAIL), a member of the tumour necrosis factor (TNF) superfamily, may also be involved in the pathogenesis of CVD. Observational studies have demonstrated that serum levels of TRAIL are inversely correlated with severity of coronary artery disease. This concurs ...

Acromegalic congestive cardiac failure (CCF) is a serious and late complication of untreated acromegaly with associated high morbidity and mortality.1 Spontaneous recovery of end stage acromegalic CCF following autoinfarction of a somatotroph adenoma has not been previously reported.We report the case of a 61-year-old woman who presented with features of severe biventricular CCF and an acromegalic phenotype. Echocardiography revealed poor LV f...

BackgroundStructured lifestyle modification programmes are offered as first line treatment to patients referred to bariatric specialist services. We sought to describe changes in anthropometric and metabolic characteristics in a cohort of bariatric patients following completion of an eight-week, multidisciplinary group-based lifestyle intervention focussed on diet and physical activity.MethodsWe conducted a p...